HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 399188Generated: October 26, 2026
Sulfur trioxide triethylamine complex → 3,5-Difluorobenzonitrile
https://huagongshe.com/reaction/399188
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfur trioxide triethylamine complex | HCID 222301 | — |
| Reactant | 3,5-Difluorobenzamide | HCID 2736910 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3,5-Difluorobenzonitrile | HCID 587204 | 85.7% |
Reaction Steps
A suspension of 10 mmol of 3,5-difluorobenzamide and 25 mmol of triethylamine-sulphur trioxide in 30 ml of triethylamine was stirred at 89° C. for 1 hour. The working up was effected as described under Example 1a). Yield: 85.7% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05817827 |
|---|
| Source dataset | uspto-grants-1998_10 |
|---|
| ORD ID | ord-caeff4bacf96472ca392dbc8cd0d0e74 |
|---|
| Source note | uspto-grants-1998_10 |
|---|
