HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-Chloro-3-(2-dimethylamino-ethoxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-Chloro-3-(2-dimethylaminoethoxy)nitrobenzene | HCID 54487390 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Chloro-3-(2-dimethylamino-ethoxy)aniline | HCID 12135420 | — |
Reaction Steps
To 4-chloro-3-(2-dimethylaminoethoxy)nitrobenzene (D5, 1.5 g, 0.006 mol) in EtOH (25 ml) at 60° C., was added SnCl2 (4.2 g) in concentrated hydrochloric acid (7.6 ml) dropwise. The mixture was then heated under reflux for 30 mins and after cooling to room temperature, diluted with water (50 ml), and basified by addition of 40% aq. sodium hydroxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05817833 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-6d7b108b4a9b4fe387f0badb00bf8f8d |
| Source note | uspto-grants-1998_10 |