2,3-Dihydro-6-(3-dimethylaminopropyl)-5-ethoxy-1H-indole → 1-(4'-Acetyl-3'-methylbiphenyl-4-carbonyl)-2,3-dihydro-6-(2-dimethylaminoethoxy)-5-methoxy-1H-indole
Reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16](O)=[O:17])=[CH:12][CH:11]=2)=[CH:6][C:5]=1[CH3:19])(=[O:3])[CH3:2].[CH3:20][N:21]([CH3:36])[CH2:22][CH2:23][O:24]N1C2C(=CC(OC)=CC=2)C=C1.CN(C)CCC[C:42]1[CH:50]=[C:49]2[C:45]([CH2:46][CH2:47][NH:48]2)=[CH:44][C:43]=1[O:51][CH2:52]C>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13]([C:16]([N:48]3[C:49]4[C:45](=[CH:44][C:43]([O:51][CH3:52])=[C:42]([O:24][CH2:23][CH2:22][N:21]([CH3:36])[CH3:20])[CH:50]=4)[CH2:46][CH2:47]3)=[O:17])=[CH:14][CH:15]=2)=[CH:6][C:5]=1[CH3:19])(=[O:3])[CH3:2]Participants
4
Reactant 3
Product 1
Procedure
The title compound was prepared from 4'-acetyl-3'-methylbiphenyl-4-carboxylic acid (D21) and 2,3-dihydro-6-(2-dimethylaminoethoxy-5-methoxy-1H-indole (D14) using a similar procedure to Example 2 as a yellow solid mp 160°-162° C. (47%).
Sources & evidence
- ORD record
- ord-700953f132f0462188e321033b233719
- Source dataset
- uspto-grants-1998_10
- Patent number
- US05817833
Reaction notes
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