Acetone → Benzenamine, 4-fluoro-N-(1-methylethyl)-

HRID 399302Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[CH3:11][C:12]([CH3:14])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH:12]([CH3:14])[CH3:11])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 180Acetone2×

HCID 9590p-Fluoronitrobenzene

Product 1

HCID 154403Benzenamine, 4-fluoro-N-(1-methylethyl)-Yield 90%

Procedure

A process according to claim 1, wherein the N-alkyl-arylamine (I) is of the formula ##STR31## 4-fluoro-nitrobenzene is employed as the nitroarene and acetone as the carbonyl compound, the reaction mixture consisting of the stated catalyst and the reactants, wherein the acetone is employed in excess and constitutes the sole diluent for the reaction, the 4-fluoro-N-isopropyl-aniline of the above formula (3) being produced in a yield of at least 90% of theory.

Workup

customfor the reaction

Sources & evidence

ORD record: ord-f83cb76296b542efa6f309011204a7c0
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05817876

Reaction notes

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