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Pentane → 4,4,4-Trifluorobutanoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pentane | HCID 8003 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 4,4,4-Trifluorobutanoic acid | HCID 2777085 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4,4,4-Trifluorobutanoyl chloride | HCID 15104474 | 76% |
反応手順
To a mixture of 131 g of 4,4,4-trifluorobutyric acid and 1 liter of pentane, 101 ml of oxalyl chloride and 0.1 ml of dimethylformamide were added, and the mixture was heated at reflux for 3 hours. The reaction solution was distilled at normal pressure to give 112 g of 4,4,4-trifluorobutyryl chloride (b.p. 103° C., 760 mmHg) (yield: 76%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05817880 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-dda02cccbd384cfaa43ae6df5137b990 |
| 出典メモ | uspto-grants-1998_10 |