反应详情

0.5 g (2.26 mmol) of alcohol 1b in solution in 3 cm3 of acetone were introduced into a 10-cm3 round bottom flask fitted with a condenser and with magnetic stirring. 5 cm3 of the Jones reactant were introduced gently; the reaction was highly exothermic; the reaction mixture was then heated to 45°-50° C. for 16 h (1 cm3 of Jones reactant having been added after 4 h and 2 cm3 after 9 h of reaction). At the end of reaction the Jones reactant was destroyed with 10 cm3 of isopropanol, the mixture was diluted with 10 cm3 of water, extracted with dichloromethane and dried over magnesium sulfate, and the solvents were evaporated off. The material was incorporated onto silica and purified by flash chromatography. 0.16 g of starting alcohol 1b (32%) and 0.30 g of pure diol 3a were isolated, that was a 56% yield of compound 3a (Yld based on the unrecovered alcohol 1b =85%). m.p.=42°-43° C. 1H NMR (CDCl3): 3.75 (s, 1H mobile); 3.60 (s, 1H mobile); 2.70-1.40 (m, 6H). IR in cm-1 (CDCl3): νOH =3540 (very broad). Microanalysis: C6 H8Cl3FO; Th.: % C 30.34 % H 3.39; F.: 30.26 3.15

1. customfitted with a condenser and with magnetic stirring
2. addition5 cm3 of the Jones reactant were introduced gently
3. temperaturethe reaction mixture was then heated to 45°-50° C. for 16 h
4. addition(1 cm3 of Jones reactant having been added after 4 h and 2 cm3 after 9 h of reaction)
5. customAt the end of reaction the Jones reactant
6. customwas destroyed with 10 cm3 of isopropanol
7. additionthe mixture was diluted with 10 cm3 of water
8. extractionextracted with dichloromethane
9. dry with materialdried over magnesium sulfate
10. customthe solvents were evaporated off
11. custompurified by flash chromatography