HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-Bromo-3-chloro-3-fluoro-7-oxabicyclo[4.1.0]heptane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,3-Dichloro-3-fluoro-7-oxabicyclo[4.1.0]heptane | HCID 18970966 | — |
| Reactant | 2-Bromo-2,6-dichloro-6-fluorocyclohexanol | HCID 18970968 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Bromo-3-chloro-3-fluoro-7-oxabicyclo[4.1.0]heptane | HCID 18970943 | 80% |
Reaction Steps
The same procedure was followed as for the production of 2e in Example 17: it was performed with 0.20 g (0.75 mmol) of alcohol 1i, 3 cm3 of water and 0.12 g (3 mmol) of sodium hydroxide. Reaction time: 1 h 15 min; ether extraction (4×7 cm3). After treatment, 0.15 g of epoxide 2g were obtained (macrobore GC purity>97.5%), having a yield of 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05817890 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-c774fd78aad1421d9ad02b0f0b1d2519 |
| Source note | uspto-grants-1998_10 |