反应详情

0.84 g (3.69 mmol) of epoxide 2i in solution in 4 cm3 of anhydrous DMF were heated to reflux for 3 h 30 min. The solution was acidified (pH=1) with 3N HCl, extracted with ether (4×20 cm3), dried over MgSO4, filtered and evaporated down. The crude product obtained was purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95). 0.43 g of phenol 4f were obtained (macrobore GC purity>99%). The yield of compound 4f was 75.5%.

1. temperatureto reflux for 3 h 30 min
2. extractionextracted with ether (4×20 cm3)
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. customevaporated down
6. customThe crude product obtained
7. customwas purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95)