Ethanol → HCID 86753204, compound

Participants

Reaction Conditions

Reaction Steps

N-(t-Butyloxy)-2-(R)-[(4-methoxybenzenesulfonyl)(4-picolyl)amino]-2-[(N-(2-(1-naphthyl)-ethoxycarbonyl))-4-piperidinyl]acetamide (3 g, 4.65 mmol) is dissolved in methylene chloride (100 ml) containing ethanol (0.27 ml, 4.6 mmol) and the reaction mixture is cooled to -10° C. Hydrochloric acid gas (from a lecture bottle) is bubbled trough the solution for 15 minutes. The flask is sealed, the reaction mixture is allowed to slowly warm to room temperature and stirred at room temperature for 6 days. The reaction mixture is concentrated in vacuo to provide N-hydroxy-2-(R)-[(4-methoxy-benzenesulfonyl) (4-picolyl)amino]-2- [(N-(2-(1-naphthyl)-ethoxycarbonyl))-4-piperidinyl]acetamide hydrochloride as a white solid, m.p. >137° C. (dec).

Provenance & Evidence