HRID399353

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCN(Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1)c1nn(CCc2ccccc2)c(Br)c1C(=O)OCC

HCID22103828

未命名化合物

PRODUCTS

生成物

结构：CCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nn(CCc2ccccc2)c(Br)c1C(=O)OCC

HCID178457033

未命名化合物

收率 87.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

356 mg of N-[1-(2-phenylethyl)-4-ethoxycarbonyl-5-bromopyrazol-3-yl]-N-[(2'-(N-triphenylmethyl-(1H-tetrazol-5-yl))biphenyl-4-yl)methyl]-n-propylamine were dissolved in 5 ml of ethanol and heated under reflux for 2 hours, and the solvent was distilled off under reduced pressure. The resulting residue was subjected to silica gel column chromatography (n-hexane--ethyl acetate=2:1→ethyl acetate) to obtain 224 mg of the intended compound as a pale yellow, amorphous solid.

WORKUP

后处理

temperatureheated
temperatureunder reflux for 2 hours
distillationthe solvent was distilled off under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ffd3da8c6e974082832ca52b160526f4
来源数据集: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05817828
来源说明: uspto-grants-1998_10

反应 SMILES

[C:1]1([CH2:7][CH2:8][N:9]2[C:13]([Br:14])=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:11]([N:20]([CH2:58][CH2:59][CH3:60])[CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[N:38](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[N:37]=[N:36][N:35]=4)=[CH:24][CH:23]=3)=[N:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C>[C:1]1([CH2:7][CH2:8][N:9]2[C:13]([Br:14])=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:11]([N:20]([CH2:58][CH2:59][CH3:60])[CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[NH:38][N:37]=[N:36][N:35]=4)=[CH:24][CH:23]=3)=[N:10]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1