Colfosceril Palmitate → ethanol DPPC

HRID 399366Notes

Reaction equation

HRID 399366 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][C@@H:20]([O:33][C:34]([CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])=[O:35])[CH2:21][O:22][P:23]([O:26][CH2:27][CH2:28][N+:29]([CH3:32])([CH3:31])[CH3:30])([O-:25])=[O:24])=[O:17]>C(O)C.[Na+].[Cl-].C(O)C(N)(CO)CO>[CH2:16]([OH:17])[CH3:15].[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][C@@H:20]([O:33][C:34]([CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])=[O:35])[CH2:21][O:22][P:23]([O:26][CH2:27][CH2:28][N+:29]([CH3:32])([CH3:31])[CH3:30])([O-:25])=[O:24])=[O:17]

Participants

3

Reactant 1

HCID 452110Colfosceril Palmitate

Product 1

HCID 131720878ethanol DPPC

Reagents, catalysts & solvents 1

HCID 131720879ethanol NaCl TrisSolvent2×

Procedure

FIG. 24. Phase contrast photomicrographs of the ethanol-induced DPPC interdigitated sheets and DPPC IFVs. A. Photomicrographs (400×) of ethanol-induced DPPC interdigitated sheets formed at 20 mg/ml (3.0M ethanol, 150 mM NaCl, 10 mM Tris-HCl, pH 7.2, room temperature). The sheet suspension was then disrupted by a five-fold dilution with 3.0M ethanol NaCl/Tris buffer. B. Photomicrograph (400×) of 20 mg/ml DPPC IFVs in 3.0M ethanol NaCl/Tris buffer at room temperature. The IFVs were formed from ethanol/DPPC interdigitated sheets by raising the sample temperature above the Tm of the DPPC. The scale bars in both micrographs indicate 10 microns.

Workup

  1. customat room temperature

Sources & evidence

ORD record
ord-f65272689f154ed1a5539dba02f750ed
Source dataset
uspto-grants-1998_10
Patent number
US05820848

Reaction notes

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