反应详情

温度

100 °C

4-Amino-3-pyridinol (3.3 g) was added to 1-piperidinylformamide dimethyl acetal (50 ml) and the mixture was stirred at 100° C. until it became homogeneous (approximately one minute). The reaction mixture was cooled, and placed in an ice bath for a half hour. The crystallized product was filtered, washed well with diethyl ether, and air dried to yield 4.64 g of product. This was recrystallized from ethyl acetate and dried under high vacuum and refluxing ethanol overnight to yield 3.39 g of fluffy needles, m.p. 171°-172.5° C.

1. custom(approximately one minute)
2. temperatureThe reaction mixture was cooled
3. waitplaced in an ice bath for a half hour
4. filtrationThe crystallized product was filtered
5. washwashed well with diethyl ether, and air
6. customdried