1,4-Dioxane hydrochloride → HCID 67538397, compound

HRID 39940Notes

Reaction equation

HRID 39940 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][N:12]([CH:20]3[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][N:28]4[C:37]5[C:32](=[C:33]([NH:38][C:39]([NH:41][CH2:42][CH3:43])=[O:40])[CH:34]=[CH:35][CH:36]=5)[CH:31]=[CH:30][C:29]4=[O:44])[CH2:22][CH2:21]3)C(=O)OC(C)(C)C)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1.[ClH:45].O1CCOCC1>O1CCOCC1>[ClH:45].[CH2:42]([NH:41][C:39]([NH:38][C:33]1[CH:34]=[CH:35][CH:36]=[C:37]2[C:32]=1[CH:31]=[CH:30][C:29](=[O:44])[N:28]2[CH2:27][CH2:26][N:23]1[CH2:24][CH2:25][CH:20]([NH:12][CH2:11][C:9]2[CH:8]=[CH:7][C:6]3[O:1][CH2:2][CH2:3][O:4][C:5]=3[CH:10]=2)[CH2:21][CH2:22]1)=[O:40])[CH3:43]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59398068HCID 59398068, compound

Product 1

HCID 67538397HCID 67538397, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 55 mg of tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(5-(3-ethylureido)-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 3 mL of 1,4-dioxane and 1 mL of 4 mol/L hydrogen chloride/1,4-dioxane were added, and stirred at room temperature for 3 hours. The resulting solid was filtered to give 26 mg of 1-ethyl-3-(1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)quinolin-2(1H)-on-5-yl)urea hydrochloride as a yellow solid.

Workup

  1. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-f3a8591b89074649ada4d096b0bd5b3e
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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