Trimethylsilyl iodide → HCID 86753212, compound

Participants

Reaction Steps

A solution of 1-6 (64 mg, 0.129 mmole) in acetonitrile (15 ml) at 0° was treated with iodotrimethylsilane (107.0 mg, 0.533 mmole) and the reaction stirred 0.5 h. The reaction was quenched into water, extracted with diethyl ether and chromatographed on silica using EtOH/NH4 OH/H2O (10/1/1) to give upon concentration a white foam. Crystallization from ethanol gave 1-7 as a white solid, mp 267°-269°. ##STR40## 2(S)-[6-Butylsulfonyl)amino]-3[[[2,3-dihydro-3-oxo-2-[2-(N-CBZ-Piperidin-4-yl)ethyl]-1,2,4 -triazolo[4,3-a]Pyridin-6-yl]carbonyl[amino Propionic acid (1-8)

Provenance & Evidence