HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 67661919, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Dimethyl 1-(2-bromoethyl)-1H-pyrazole-3,5-dicarboxylate | HCID 1484510 | — |
| Reactant | tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate | HCID 1514258 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 67661919 | HCID 67661919 | — |
Reaction Steps
A solution of 3-2 (14.0 g, 48.0 mmol), diisopropylethyl amine (25 ml, 144 mmol), Boc-4-aminoethylpiperidine (12.0 g, 52.6 mmol), and potassium iodide (2.39 g, 0.3 mmol) in 250 ml CH3CN was refluxed under N2 for 4.5 h then cooled, filtered and evaporated at reduced pressure. The resulting yellow residue was chromatographed on silica gel using EtOAc as eluent to give 3-3 as an off-white crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821241 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-ebb972f759d446a28838b3d6fdf12e20 |
| Source note | uspto-grants-1998_10 |