Acetic Anhydride → HCID 70084326, compound

Participants

Reaction Steps

Acetic anhydride (70 ml, 0.76 mmol), was added to a cooled (0°) solution of 4-3 (350 mg, 0.69 mmol) in 10 ml THF. The resulting solution was allowed to warm to room temperature and stirred for 18 h, then concentrated, and the residue was dissolved in 50 ml ethyl acetate and washed successively with NaHCO3, H2O, 10% KHSO4, H2 O, and brine (25 ml each). The organic layer was dried over Na2 SO4 and evaporated giving a colorless residue which was chromatographed on silica gel with 3% CH3OH/CH2Cl2 to yield 4-4 as a white solid.

Provenance & Evidence