1,4-Dioxane hydrochloride → HCID 67538034, compound

HRID 39944Notes

Reaction equation

HRID 39944 reaction equation
[CH3:1][O:2][C:3](=[O:43])[NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9](=[O:42])[N:10]2[CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH:20]([N:23](C(OC(C)(C)C)=O)[CH2:24][C:25]2[CH:34]=[CH:33][C:28]3[O:29][CH2:30][CH2:31][O:32][C:27]=3[CH:26]=2)[CH2:19][CH2:18]1.[ClH:44].O1CCOCC1>O1CCOCC1>[ClH:44].[CH3:1][O:2][C:3](=[O:43])[NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9](=[O:42])[N:10]2[CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][CH:20]([NH:23][CH2:24][C:25]2[CH:34]=[CH:33][C:28]3[O:29][CH2:30][CH2:31][O:32][C:27]=3[CH:26]=2)[CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59398179HCID 59398179, compound

Product 1

HCID 67538034HCID 67538034, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 35 mg of N-(1-(2-(4-((tert-butoxycarbonyl)(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-2-oxo-1,2-dihydroquinolin-5-yl)carbamic acid methyl ester, 2 mL of 1,4-dioxane and 0.8 mL of 4 mol/L hydrogen chloride/1,4-dioxane were added, and stirred at room temperature for 3 hours. The resulting solid was filtered to give 23 mg of N-(1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-2-oxo-1,2-dihydroquinolin-5-yl)carbamic acid methyl ester hydrochloride as a yellow solid.

Workup

  1. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-f441cb2839e643599e38f8e9f74b50e6
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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