4-Chloro-6,7-dimethoxyquinazoline hydrochloride → HCID 18967662, compound

HRID 399457Notes

Reaction equation

HRID 399457 reaction equation
[S:1]1[C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=2[Cl:15])=[O:7])=[CH:4][N:3]=[CH:2]1.Cl.Cl[C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[ClH:15].[Cl:15][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][C:8]=1[C:6]([C:5]1[S:1][CH:2]=[N:3][CH:4]=1)=[O:7])[NH:14][C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1

Participants

3

Reactant 2

HCID 220221614-Chloro-6,7-dimethoxyquinazoline hydrochlorideHCID 545477704-Amino-2-chlorophenyl 5-thiazolyl ketone

Product 1

HCID 18967662HCID 18967662, compoundYield 31%

Procedure

Using an analogous procedure to that described in Example 1, 4-amino-2-chlorophenyl 5-thiazolyl ketone was reacted with 4-chloro-6,7-dimethoxyquinazoline hydrochloride to give 4-[3-chloro-4-(5-thiazolylcarbonyl)anilino]-6,7-dimethoxyquinazoline hydrochloride salt in 31% yield, m.p. 254°-257° C.;

Sources & evidence

ORD record
ord-b7f749bf588b4d7aa25a7c798666d8c6
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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