HCID 18967679, compound → HCID 18967639, compound

HRID 399466Notes

Reaction equation

HRID 399466 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=2[Cl:15])=[CH:2]1.Cl.Cl[C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[ClH:15].[Cl:15][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][C:8]=1[O:7][CH2:6][C:3]1[CH:4]=[CH:5][O:1][CH:2]=1)[NH:14][C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1

Participants

3

Reactant 2

HCID 18967679HCID 18967679, compoundHCID 220221614-Chloro-6,7-dimethoxyquinazoline hydrochloride

Product 1

HCID 18967639HCID 18967639, compoundYield 79%

Procedure

Using an analogous procedure to that described in Example 1 except that the reaction mixture was heated to reflux for 6 hours, 4-amino-2-chlorophenyl 3-furylmethyl ether was reacted with 4-chloro-6,7-dimethoxyquinazoline hydrochloride to give 4-[3-chloro-4-(3-furylmethoxy)anilino]-6,7-dimethoxyquinazoline hydrochloride salt in 79% yield, m.p. 244°-246° C.;

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 6 hours

Sources & evidence

ORD record
ord-f389755aa8b94890ad8bbed42ae28dba
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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