2-Chloro-1-fluoro-4-nitrobenzene → 3-Chloro-4-(2-thiazolylthio)nitrobenzene

Participants

Reaction Steps

Using an analogous procedure to that described in the first paragraph of the portion of Example 8 which is concerned with the preparation of starting materials, 3-chloro-4-fluoronitrobenzene was reacted with 2-thiazolethiol to give a precipitated solid which was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated to give 2-chloro-4-nitrophenyl 2-thiazolyl sulphide in 26% yield.

Provenance & Evidence