2-Chloro-1-fluoro-4-nitrobenzene → HCID 18967701, compound

HRID 399474Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[CH2:17][OH:18]>>[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[CH2:17][O:18][C:7]1[CH:6]=[CH:5][C:4]([N+:9]([O-:11])=[O:10])=[CH:3][C:2]=1[Cl:1]

Participants

Reactant 2

HCID 676882-Chloro-1-fluoro-4-nitrobenzene

HCID 694672-Thiophenemethanol

Product 1

HCID 18967701HCID 18967701, compoundYield 40%

Procedure

Using an analogous procedure to that described in the first paragraph of the portion of Example 8 which is concerned with the preparation of starting materials, 3-chloro-4-fluoronitrobenzene was reacted with 2-thienylmethanol to give 2-chloro-4-nitrophenyl 2-thienylmethyl ether in 40% yield.

Sources & evidence

ORD record: ord-4d49932b19e345919e8865e053e0aeae
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05821246

Reaction notes

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