4-Amino-2-chlorobenzophenone → 4-(4-Benzoyl-3-chloroanilino)-6,7-di-(2-methoxyethoxy)quinazoline hydrochloride salt

HRID 399480Notes

Reaction equation

HRID 399480 reaction equation
Cl.[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:18][CH2:19][CH2:20][O:21][CH3:22])=[C:10]([O:13][CH2:14][CH2:15][O:16][CH3:17])[CH:11]=2)[N:6]=[CH:5][N:4]=1.[NH2:23][C:24]1[CH:37]=[CH:36][C:27]([C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:29])=[C:26]([Cl:38])[CH:25]=1>>[ClH:2].[C:28]([C:27]1[CH:36]=[CH:37][C:24]([NH:23][C:3]2[C:12]3[C:7](=[CH:8][C:9]([O:18][CH2:19][CH2:20][O:21][CH3:22])=[C:10]([O:13][CH2:14][CH2:15][O:16][CH3:17])[CH:11]=3)[N:6]=[CH:5][N:4]=2)=[CH:25][C:26]=1[Cl:38])(=[O:29])[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 117364064-Amino-2-chlorobenzophenoneHCID 189675594-Chloro-6,7-di-(2-methoxyethoxy)quinazoline hydrochloride

Product 1

HCID 189676674-(4-Benzoyl-3-chloroanilino)-6,7-di-(2-methoxyethoxy)quinazoline hydrochloride saltYield 32%

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-6,7-di-(2-methoxyethoxy)quinazoline hydrochloride was reacted with 4-amino-2-chlorobenzophenone to give 4-(4-benzoyl-3-chloroanilino)-6,7-di-(2-methoxyethoxy)quinazoline hydrochloride salt in 32% yield, m.p. 242°-244° C.;

Sources & evidence

ORD record
ord-ef96cf0a00c44264a1de03f5fb6b6a89
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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