4-Amino-2-chlorobenzophenone → 6-Acetoxy-4-(4-benzoyl-3-chloroanilino)quinazoline hydrochloride salt

HRID 399481Notes

Reaction equation

HRID 399481 reaction equation
Cl.[C:2]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[Cl:16])(=[O:4])[CH3:3].[NH2:17][C:18]1[CH:31]=[CH:30][C:21]([C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:23])=[C:20]([Cl:32])[CH:19]=1>>[ClH:16].[C:2]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[NH:17][C:18]1[CH:31]=[CH:30][C:21]([C:22](=[O:23])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:20]([Cl:32])[CH:19]=1)(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 117364064-Amino-2-chlorobenzophenoneHCID 189676236-Acetoxy-4-chloroquinazoline hydrochloride

Product 1

HCID 189675936-Acetoxy-4-(4-benzoyl-3-chloroanilino)quinazoline hydrochloride saltYield 47%

Procedure

Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloroquinazoline hydrochloride was reacted with 4-amino-2-chlorobenzophenone to give 6-acetoxy-4-(4-benzoyl-3-chloroanilino)quinazoline hydrochloride salt in 47% yield, m.p. >250° C.;

Sources & evidence

ORD record
ord-322b08e1ff5645d8b78358825d873e26
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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