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4-Chloro-6-methoxyquinazolin-7-yl acetate → 7-Acetoxy-6-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-6-methoxyquinazolin-7-yl acetate | HCID 22243885 | — |
| 反応物 | 3-Methyl-4-(pyridin-2-ylmethoxy)aniline | HCID 23438288 | — |
| 生成物 | 7-Acetoxy-6-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline | HCID 18967657 | 64% |
反応手順
Using an analogous procedure to that described in Example 1 except that the reaction mixture was heated to reflux for 3 hours, 7-acetoxy-4-chloro-6-methoxyquinazoline was reacted with 5-amino-2-tolyl 2-pyridylmethyl ether to give 7-acetoxy-6-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline in 64% yield;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05821246 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-2670b9d7cc724f1aac0441a748810cc1 |
| 出典メモ | uspto-grants-1998_10 |