1,2-Dibromoethane → HCID 18967587, compound

HRID 399486Notes

Reaction equation

HRID 399486 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[S:20][C:21]1[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=1)[NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([OH:16])[CH:14]=2)[N:9]=[CH:8][N:7]=1.[Br:27][CH2:28][CH2:29]Br>>[Br:27][CH2:28][CH2:29][O:16][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][N:7]=[C:6]2[NH:5][C:4]1[CH:17]=[CH:18][C:19]([S:20][C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[C:2]([F:1])[CH:3]=1

Participants

3

Reactant 2

HCID 78391,2-DibromoethaneHCID 18967645HCID 18967645, compound

Product 1

HCID 18967587HCID 18967587, compoundYield 45%

Procedure

Using an analogous procedure to that described in Example 22, a mixture of 4-[3-fluoro-4-(1-methylimidazol-2-ylthio)anilino]-6-hydroxyquinazoline was reacted with 1,2-dibromoethane to give 6-(2-bromoethoxy)-4-[3-fluoro-4-(1-methylimidazol-2-ylthio)anilino]quinazoline in 45% yield;

Sources & evidence

ORD record
ord-71523231262447959350c23e50a63af7
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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