HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-7-methoxyquinazolin-6-yl acetate--hydrogen chloride (1/1) → 6-Acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-7-methoxyquinazolin-6-yl acetate--hydrogen chloride (1/1) | HCID 22022159 | — |
| Reactant | 3-Methyl-4-(pyridin-2-ylmethoxy)aniline | HCID 23438288 | — |
| Product | 6-Acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline | HCID 18967644 | 60% |
Reaction Steps
Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloro-7-methoxyquinazoline, hydrochloride salt, was reacted with 5-amino-2-tolyl 2-pyridylmethyl ether to give 6-acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline in 60% yield;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821246 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-b3526fe5e063495b896cd4af83ece54b |
| Source note | uspto-grants-1998_10 |