4-(3-Chloropropyl)morpholine → HCID 18967566, compound

HRID 399491Notes

Reaction equation

HRID 399491 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)=[C:17]([CH3:29])[CH:16]=1.[O:30]1[CH2:35][CH2:34][N:33]([CH2:36][CH2:37][CH2:38]Cl)[CH2:32][CH2:31]1>>[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:4]([C:5]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[C:17]([CH3:29])[CH:16]=3)=[N:6][CH:7]=[N:8]2)=[CH:3][C:2]=1[O:1][CH2:38][CH2:37][CH2:36][N:33]1[CH2:34][CH2:35][O:30][CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 958344-(3-Chloropropyl)morpholineHCID 18967588HCID 18967588, compound

Product 1

HCID 18967566HCID 18967566, compoundYield 53%

Procedure

Using an analogous procedure to that described in Example 38, 6-hydroxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline was reacted with 3-morpholinopropyl chloride to give 7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]-6-(3-morpholinopropoxy)quinazoline in 53% yield;

Sources & evidence

ORD record
ord-b4aa8c99f986475882881a8ca203feee
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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