HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6-nitroquinazoline → 4-[2-Fluoro-4-(2-pyridylmethoxy)anilino]-6-nitroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6-nitroquinazoline | HCID 11356257 | — |
| Reactant | 4-Amino-3-fluorophenyl 2-pyridylmethyl ether | HCID 21847822 | — |
| Product | 4-[2-Fluoro-4-(2-pyridylmethoxy)anilino]-6-nitroquinazoline | HCID 18967656 | 98% |
Reaction Steps
Using an analogous procedure to that described in the first paragraph of the portion of Example 42 which is concerned with the preparation of starting materials, 4-chloro-6-nitroquinazoline was reacted with 4-amino-3-fluorophenyl 2-pyridylmethyl ether to give 4-[2-fluoro-4-(2-pyridylmethoxy)anilino]-6-nitroquinazoline in 98% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821246 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-8c2d43b142324a1f9fe107e7d37a5250 |
| Source note | uspto-grants-1998_10 |