HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,2-Trimethoxyethane → 4-[2-Fluoro-4-(2-pyridylmethoxy)anilino]-6-(2-methoxyethylamino)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,2-Trimethoxyethane | HCID 47520 | — |
| Reactant | 6-Amino-4-[2-fluoro-4-(2-pyridylmethoxy)anilino]quinazoline | HCID 18967632 | — |
| Product | 4-[2-Fluoro-4-(2-pyridylmethoxy)anilino]-6-(2-methoxyethylamino)quinazoline | HCID 18967619 | 52% |
Reaction Steps
Using an analogous procedure to that described in Example 43, 6-amino-4-[2-fluoro-4-(2-pyridylmethoxy)anilino]quinazoline was reacted with 2-methoxyacetaldehyde dimethyl acetal to give 4-[2-fluoro-4-(2-pyridylmethoxy)anilino]-6-(2-methoxyethylamino)quinazoline in 52% yield;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821246 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-9678819deb964f38938d0719a6271f81 |
| Source note | uspto-grants-1998_10 |