Hydrogen chloride-ethyl acetate → 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride

HRID 39952Notes

Reaction equation

HRID 39952 reaction equation
[CH2:1]([C:3]1[CH:35]=[CH:34][C:6]([CH2:7][NH:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=4)[C:20]([C:29]([NH:31][CH3:32])=[O:30])=[CH:19][C:18]3=[O:33])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[ClH:36].C(OCC)(=O)C>CO>[ClH:36].[CH2:1]([C:3]1[CH:35]=[CH:34][C:6]([CH2:7][NH:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][N:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=4)[C:20]([C:29]([NH:31][CH3:32])=[O:30])=[CH:19][C:18]3=[O:33])[CH2:13][CH2:14]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593980151-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

Product 1

HCID 675376111-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 2 mL of a methanol solution containing 0.14 g of 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added at room temperature, and the solvent was removed under reduced pressure. Ethyl acetate was added to the residue thus obtained, and the resulting solid was filtered to give 0.15 g of 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride as a pale yellow solid.

Workup

  1. additionwas added at room temperature
  2. customthe solvent was removed under reduced pressure
  3. additionEthyl acetate was added to the residue
  4. customthus obtained
  5. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-4e3a52c7dc1144b5993f9b39d3a77104
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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