Hydrochloric Acid → HCID 178478855, compound

Participants

Reaction Steps

(4S)-1-(tert-Butyloxycarbonyl)-4-[(isothioureido)methyl]-L-proline tert-butyl ester (25 mg, 0.070 mmol) was treated with 4N HCl in dioxane (1 mL) for 18 hours at room temperature. The reaction mixture was evaporated under diminished pressure, coevaporated several times with diethyl ether, several times with methanol, and finally ether. The product was dried under high vacuum to afford the title compound; yield 14 mg (73%). Mass spectrum: m/z 203 (M); 400 MHz 1H NMR (CD3OD): δ1.92 (m, 1H); 3.18 (m, 1H); 4.48 (m, 1H).

Provenance & Evidence