tert-Butyl 4-aminoazepane-1-carboxylate → 1-Boc-4-(aminomethyl)piperidine

HRID 399551Notes

Reaction equation

HRID 399551 reaction equation
[NH2:1][CH:2]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4][CH2:3]1>C(Cl)Cl.CO>[NH2:1][CH2:2][CH:8]1[CH2:7][CH2:6][N:5]([C:9]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:10])[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 18946151tert-Butyl 4-aminoazepane-1-carboxylate

Product 1

HCID 7368171-Boc-4-(aminomethyl)piperidine

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

4-Amino-1-tert-butyloxycarbonylazacycloheptane colourless oil; RF : 0.36 (alumina; methylene chloride/methanol=9:1)

Sources & evidence

ORD record
ord-8559b6e0e6b14e9c8a4754ce50b791e7
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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