反应详情

3.0 g of 4-chloro-6-methylthiopyrimido[5,4-d]pyrimidine, 3.8 g of 3-chloro-4-fluoroaniline and 10 ml of dioxane are heated at 80° C. for 2 hours. After cooling, the reaction mixture is concentrated and portions are triturated first with water and then with diethyl ether, filtered off with suction and dried.

1. temperatureAfter cooling
2. concentrationthe reaction mixture is concentrated
3. customportions are triturated first with water
4. filtrationwith diethyl ether, filtered off with suction
5. customdried