3-Chloro-4-fluoroaniline → HCID 21830556, compound

HRID 399555Notes

Reaction equation

HRID 399555 reaction equation
Cl[C:2]1[C:3]2[N:11]=[C:10]([S:12][CH3:13])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[Cl:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][C:21]=1[F:22])[NH2:18]>O1CCOCC1>[Cl:14][C:15]1[CH:16]=[C:17]([NH:18][C:2]2[C:3]3[N:11]=[C:10]([S:12][CH3:13])[N:9]=[CH:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH:19]=[CH:20][C:21]=1[F:22]

Participants

4

Reactant 2

HCID 97083-Chloro-4-fluoroanilineHCID 152952158-Chloro-2-(methylsulfanyl)pyrimido[5,4-d]pyrimidine

Product 1

HCID 21830556HCID 21830556, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.0 g of 4-chloro-6-methylthiopyrimido[5,4-d]pyrimidine, 3.8 g of 3-chloro-4-fluoroaniline and 10 ml of dioxane are heated at 80° C. for 2 hours. After cooling, the reaction mixture is concentrated and portions are triturated first with water and then with diethyl ether, filtered off with suction and dried.

Workup

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture is concentrated
  3. customportions are triturated first with water
  4. filtrationwith diethyl ether, filtered off with suction
  5. customdried

Sources & evidence

ORD record
ord-2c0839ce37f9418c8b7f7c980d9e87ae
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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