Sodium Hydroxide → HCID 178507839, compound

HRID 399560Notes

Reaction equation

[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([C:27]([O:29]C)=[O:28])[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)=[CH:4][C:3]=1[Cl:31].[OH-].[Na+]>>[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][C@H:21]4[CH2:22][CH2:23][C@H:24]([C:27]([OH:29])=[O:28])[CH2:25][CH2:26]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)=[CH:4][C:3]=1[Cl:31]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 178501204HCID 178501204, compound

Product 1

HCID 178507839HCID 178507839, compound

Procedure

Prepared from 4-[(4-amino-3,5-dichlorophenyl)amino]-6-[(trans-4-methoxycarbonylcyclohexyl)amino]pyrimido[5,4-d]-pyrimidine by hydrolysis with sodium hydroxide solution. Melting point: 339° C.; Rf : 0.37 (silica gel; petroleum ether/ethyl acetate/methanol=10:10:3)

Sources & evidence

ORD record: ord-cb4c1e0aacff4e96b585c7c31becd7a8
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05821240

Reaction notes

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