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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 399562Generated: October 30, 2026

Pyrrolidine → HCID 178507837, compound

https://huagongshe.com/reaction/399562

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyrrolidineHCID 31268—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
ReactantHCID 178507839HCID 178507839—
SolventTriethylamineHCID 8471—
ProductHCID 178507837HCID 178507837—

Reaction Steps

Prepared from 4-[(4-amino-3,5-dichlorophenyl)amino]-6-[(trans-4-carboxycyclohexyl)amino]pyrimido[5,4-d]pyrimidine by reaction with O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, triethylamine and pyrrolidine. Melting point: 228°-230° C,; Rf : 0.43 (silica gel; petroleum ether/ethyl acetate/methanol=10:10:4) Calculated: C 55.09 H 5.23 N 22.35; Found: 55.07 5.19 22.33 14.22

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05821240
Source datasetuspto-grants-1998_10
ORD IDord-1df7750213844433b53743a3bfcbca8a
Source noteuspto-grants-1998_10