HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 18967285, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Triacetoxyperiodinane | HCID 159087 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 18946167 | HCID 18946167 | — |
| Product | HCID 18967285 | HCID 18967285 | — |
Reaction Steps
Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[4-hydroxy-1-piperidinyl]pyrimido[5,4-d]pyrimidine by oxidation with Dess-Martin reagent and subsequent reductive amination with pyrrolidine and sodium cyanoborohydride. Melting point: 202°-204° C.; Rf : 0.58 (alumina; petroleum ether/ethyl acetate/methanol=10:10:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821240 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-b6494dd20c954a819fb6821118ca64e4 |
| Source note | uspto-grants-1998_10 |