HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 69953070, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 69954514 | HCID 69954514 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 69953070 | HCID 69953070 | — |
Reaction Steps
Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[4-piperidinylmethylamino]pyrimido[5,4-d]pyrimidine by reaction with trifluoroacetic acid and subsequent reductive amination with formaldehyde and sodium cyanoborohydride. Melting point: 198°-201° C.; Rf : 0.65 (alumina; methylene chloride/methanol=20:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821240 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-d51e19a9cead4c958654b6bef154b96a |
| Source note | uspto-grants-1998_10 |