HCID 178523762, compound → HCID 178511536, compound

HRID 399568Notes

Reaction equation

HRID 399568 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH2:21][C@H:22]4[CH2:27][CH2:26][C@H:25]([NH:28]C(OCC5C=CC=CC=5)=O)[CH2:24][CH2:23]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH2:21][C@H:22]4[CH2:27][CH2:26][C@H:25]([NH2:28])[CH2:24][CH2:23]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 1

HCID 178523762HCID 178523762, compound

Product 1

HCID 178511536HCID 178511536, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-(trans-4-(benzyloxycarbonylamino)cyclohexylmethylamino]pyrimido-[5,4-d]pyrimidine by catalytic hydrogenation. Melting point: 166°-169° C.; Rf : 0.53 (silica gel; methylene chloride/methanol/concentrated ammonia=10:1:0.05); Mass spectrum: M+ =401/403 (Cl)

Sources & evidence

ORD record
ord-b88fcfc5cc2640088e491691791b2c37
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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