Acetic Anhydride → HCID 18946166, compound

HRID 399569Notes

Reaction equation

HRID 399569 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH2:21][CH2:22][N:23]4[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].[C:29](OC(=O)C)(=[O:31])[CH3:30]>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH2:21][CH2:22][N:23]4[CH2:28][CH2:27][N:26]([C:29](=[O:31])[CH3:30])[CH2:25][CH2:24]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18946237HCID 18946237, compound

Product 1

HCID 18946166HCID 18946166, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[2-(1-piperazinyl)ethylamino]pyrimido[5,4-d]pyrimidine by reaction with acetic anhydride. Melting point: 196°-198° C.; Rf : 0.59 (alumina; methylene chloride/methanol=10:0.4)

Sources & evidence

ORD record
ord-4366f4023e3c4db6a31104ea4cd7b164
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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