HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → HCID 18967390, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178525760 | HCID 178525760 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 18967390 | HCID 18967390 | — |
Reaction Steps
Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[trans-4-carboxycyclohexylamino]pyrimido[5,4-d]pyrimidine by reaction with O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, triethylamine and piperazine. Melting point: 178°-182° C.; Rf : 0.47 (alumina; methylene chloride/methanol=10:0.3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821240 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-22a76a59139d4d02b48eef9bc8651622 |
| Source note | uspto-grants-1998_10 |