Acetic Anhydride → 1-Benzyl-3-(3-chlorophenyl)-1-(cyanoacetyl)urea

Beteiligte Stoffe

Reaktionsschritte

A mixture of 1-benzyl-3-(3-chlorophenyl)urea (44.78 g) and cyanoacetic acid (16.11 g) was ground together and then acetic anhydride (48 ml) added. The resulting mixture was heated and stirred at 75°-80° C. for 16 h. It was then allowed to cool, diluted with ether and the product filtered off and washed with ether. This was then recrystallised from toluene with a hot filtration. Yield=20.15 g.

Herkunft & Nachweise