Hydrogen chloride-ethyl acetate → HCID 67539386, compound

HRID 39960Notes

Reaction equation

HRID 39960 reaction equation
[S:1]1[C:5]([CH2:6][NH:7][CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]3[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([F:26])[CH:24]=4)[N:19]=[CH:18][C:17]3=[O:27])[CH2:10][CH2:9]2)=[CH:4][C:3]2[CH:28]=[CH:29][CH:30]=[CH:31][C:2]1=2.[ClH:32].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:32].[S:1]1[C:5]([CH2:6][NH:7][CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]3[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([F:26])[CH:24]=4)[N:19]=[CH:18][C:17]3=[O:27])[CH2:10][CH2:9]2)=[CH:4][C:3]2[CH:28]=[CH:29][CH:30]=[CH:31][C:2]1=2

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59398093HCID 59398093, compound

Product 1

HCID 67539386HCID 67539386, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 10 mL of a chloroform solution containing 228 mg of 1-(2-(4-((benzo[b]thiophen-2-yl)methylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 247 mg of 1-(2-(4-((benzo[b]thiophen-2-yl)methylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one hydrochloride as a pale brown solid.

Workup

  1. additionwas added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-17f3c276acee41b5a6935b987a8cd176
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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