HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(hydroxymethyl)benzyl]N-propylamino}thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Borane | HCID 6331 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 18967756 | HCID 18967756 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(hydroxymethyl)benzyl]N-propylamino}thiazole | HCID 15291611 | — |
Reaction Steps
2 ml of 1N borane solution in tetrahydrofuran are added, at -7° C., to 403 mg of the compound of Example 1 in 15 ml of anhydrous tetrahyrofuran, and the mixture is then left stirring overnight. 10 ml of water and 2 ml of methanol are then added in the presence of potassium carbonate. The reaction mixture is evaporated to dryness under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821255 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-8a18c9f2dbc14621901bed39c1eb2648 |
| Source note | uspto-grants-1998_10 |