HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 399635Generated: October 30, 2026
p-Toluenesulfonic acid → 2-(2-Bromoethoxy)tetrahydro-2H-pyran
https://huagongshe.com/reaction/399635
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(2-Bromoethoxy)tetrahydro-2H-pyran | HCID 86621 | — |
Reaction Steps
12 ml of dihydropyran and 20 mg of paratoluenesulphonic acid are added to a solution of 3.7 ml of 2-bromoethanol dissolved in 100 ml of methylene chloride. After stirring for 3 hours at 20° C., the reaction medium is washed with water and then with saturated aqueous sodium chloride, and evaporated to dryness. The residue is distilled at 90° C. at a pressure of 0.5 mbar.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05821255 |
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| Source dataset | uspto-grants-1998_10 |
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| ORD ID | ord-5636258cc0ce474cbf963f08111651a1 |
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| Source note | uspto-grants-1998_10 |
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