Ethanol → HCID 21727313, compound

Participants

Reaction Steps

A solution of trans-2-(2'-azidocyclohexyloxy)-acetic acid (11.16 g, 56 mmoles) and concentrated sulphuric acid (0.8 ml) in anhydrous ethanol (30 ml) was heated for 3 hours at reflux temperature, then the mixture was poured into ice water (150 ml) and extracted with n-hexane (4×60 ml). The combined hexane phases were dried over MgSO4, filtered and the solvent was evaporated. The crude product was distilled in vacuo (boiling point: 129° C./0.67 mbar), yielding 8.6 g (68%) of the title compound in the form of a yellow oil.

Provenance & Evidence