HCID 86753230, compound → HCID 18665928, compound

HRID 399719Notes

Reaction equation

HRID 399719 reaction equation
C([N:8]([C:23]([C:25]1([CH3:36])[C:30](=[O:31])[NH:29][C:28]2[CH:32]=[CH:33][CH:34]=[CH:35][C:27]=2[S:26]1)=[O:24])[C@H:9]([C:11]([NH:13][C@@H:14]([C:20](=[O:22])[NH2:21])[CH2:15][CH2:16][C:17]([O-:19])=[O:18])=[O:12])[CH3:10])C1C=CC=CC=1>CO.[Pd]>[CH3:36][C:25]1([C:23]([NH:8][C@H:9]([C:11]([NH:13][C@@H:14]([C:20](=[O:22])[NH2:21])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[O:12])[CH3:10])=[O:24])[C:30](=[O:31])[NH:29][C:28]2[CH:32]=[CH:33][CH:34]=[CH:35][C:27]=2[S:26]1

Participants

4

Reactant 1

HCID 86753230HCID 86753230, compound

Product 1

HCID 18665928HCID 18665928, compoundYield 59.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl-N-(3,4-dihydro-2-methyl-3-oxo-2H-1,4-benzothiazine-2-carbonyl)-L-alanyl-D-isoglutaminate (485 mg, 1.06 mmoles) was dissolved in methanol (17 ml), Pd/C (10%, 75 mg) was added thereto and it was hydrogenated at normal pressure for 12 hours. After the removal of the catalyst and evaporation of the solvent, there were obtained 265 mg (59.3%) of the title product in the form of a white powder, m.p. 124°-125° C.

Workup

  1. customAfter the removal of the catalyst and evaporation of the solvent

Sources & evidence

ORD record
ord-10ee370ad0e94d4da8f3af827b2070e7
Source dataset
uspto-grants-1998_10
Patent number
US05824652

Reaction notes

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