Acetyl chloride → HCID 15289370, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 34.4 ml (490 mmol) acetyl chloride in 250 ml glacial acetic acid was added dropwise to a suspension of 105 g (380 mmol) 2-(2,3,5,6-tetrachloropyridin-4-ylamino)-ethanol in 860 ml glacial acetic acid. During this the temperature increased to 40° C. After 2 h it was poured onto ice water, filtered, washed with water, the residue was dissolved in 500 ml ethyl acetate, dried over sodium sulfate, filtered and the solvent was removed in a vacuum. 112 g (93%) acetic acid-2(2,3,5,6-tetrachloropyridin-4-ylamino)-ethyl ester was obtained and was reacted without further purification. MS (m/e)=316.

Provenance & Evidence