HCID 23206747, compound → HCID 23206752, compound

Participants

Reaction Steps

was produced analogously to example 5 in a 33% yield. Oil. MS (m/e)=532. For this 2-propyloxy-benzene-sulfonyl chloride was used in step 5c) instead of 2-methoxy-benzenesulfonyl chloride and one obtained N-(3cyanomethoxy-5-methyl-phenyl)-2-propyloxy-benzene-sulfonamide (Fp. 154°-155° C.) in a 57% yield, which was reacted to N-(dimethyloxo-phosphinyl-methyl)-N-(3-cyanomethoxy-5-methyl-phenyl)-2-propyloxy-benzene-sulfonamide (60% yield, Fp. 143°-145° C.) analogously to example 5d), which was reacted analogously to example 5e) to form N-(dimethyloxophosphinyl-methyl)-N-[3-(2-amino-ethoxy)-5-methyl-phenyl]-2-propyloxy-benzene-sulfonamide (86% yield, oil, MS (m/e)=454), which was reacted analogously to example 5f) to form a mixture of N-(dimethyloxophosphinyl-methyl)-N-{3-[2-(3,5-dichloropyridazin-4-ylamino)-ethoxy]-5-methyl-phenyl}-2-propyloxy-benzenesulfonamide and N-(dimethyloxo-phosphinyl-methyl)-N-{3-[2-(3,4-dichloropyridazin-5-ylamino)-ethoxy]-5-methyl-phenyl}-2-propyloxy-benzene-sulfonamide (quant., oil, MS (m/e)=601) from which the title compound was obtained by catalytic hydrogenation analogously to example 5g).

Provenance & Evidence