HCID 67677187, compound → HCID 18944988, compound

Participants

Reaction Steps

was produced in a 35% yield analogously to example 5. Oil. MS (m/e)=532. For this 2-isopropyloxy-benzene-sulfonyl chloride was used in step 5c) instead of 2-methoxy-benzenesulfonyl chloride and N-(3-cyanomethoxy-5-methyl-phenyl)-2-(2-propyloxy)-benzenesulfonamide (Fp. 100°-102° C.) was obtained in a 21% yield which was reacted analogously to example 5d) to form N-(dimethyloxophosphinyl-methyl)-N-(3-cyanomethoxy-5-methyl-phenyl)-2-(2-propyloxy)-benzenesulfonamide (65% Fp. 137°-140° C.) and this was reacted analogously to example 5e) to form N-(dimethyloxophosphinyl-methyl)-N-[3-(2-amino-ethoxy)-5-methyl-phenyl]-2-(2-propyloxy)-benzene sulfonamide (75% oil, MS (m/e)=454) which was reacted analogously to example 5f) to form a mixture of N-(dimethyloxophosphinyl-methyl)-N-{3-[2-(3,5-dichloro-pyridin-4-ylamino)-ethoxy]-5-methyl-phenyl}-2-(2-propyloxy)-benzenesulfonamide and N-(dimethyloxo-phosphinyl-methyl)-N-{3-[2-(3,4-dichloro-pyridin-5-ylamino)-ethoxy]5-methyl-phenyl}-2-(2-propyloxy)-benzenesulfonamide (quant., oil, MS (m/e)=601) from which the title compound was obtained analogously to example 5g) by catalytic hydrogenation.

Provenance & Evidence