反应详情

温度

105 °C

To the mixture of methyl 3-(2-trimethylammoniomethyl-pyrrol-1-yl)benzoate iodide (2.0 g) and 1,3-dimethyl-imidazolidin-2-one (6 ml) was added borane-pyridine complex (1.1 ml) and the mixture was stirred for 1.5 hours at 105° C. To the mixture was added dichloromethane, and the mixture was washed with water, 1N-hydrochloric acid and water successively. The mixture was dried over magnesium sulfate and evaporated in vacuo to give methyl 3-(2-methylpyrrol-1-yl)benzoate (1.01 g) as an oil.

1. additionwas added borane-pyridine complex (1.1 ml)
2. washthe mixture was washed with water, 1N-hydrochloric acid and water successively
3. dry with materialThe mixture was dried over magnesium sulfate
4. customevaporated in vacuo